© Neuroscience-Net Volume 1, Article #10005

Received June 6, 1996 Accepted for Publication July 8, 1996 Published July 30, 1996

Send correspondence to:

Professor Remi Quirion
Dept. of Psychiatry
Douglas Hospital Res Ctr
6875 Blvd lasalle Verdun
Quebec, Canada H4H 1R3
E-mail:MCOU@MusicA.McGill.ca

KEY WORDS: Receptor Autoradiography, Hippocampus, D1 receptors, Monkey, Human, Rat.

The distributional profile of [³H] SCH 23390/dopamine D1-like receptors in the hippocampal formation of the rat, monkey and human brains was examined by quantitative receptor autoradiography. D1-like receptors were found in the hippocampus of all three species. In the rat, the majority of these receptors were located in the molecular layer of the dentate gyrus whereas the Ammon's horn subfields exhibited lower levels of D1-like binding sites. Interestingly, this distribution profile was reversed in the primate hippocampus. In both the monkey and human hippocampus, the highest D1-like receptor density was seen in the CA1 followed by the CA3 subfields, with the dentate gyrus containing lower levels. These results demonstrate that, in contrast to the situation seen in the basal ganglia, D1-like receptor distribution in the hippocampal formation may not be evolutionary conserved.